| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Uitoefening | 39.000 | US$ 25 | — | 154.745 |
| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Uitoefening | 39.650 | US$ 18 | — | 194.395 |
| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 63.907 | US$ 62 | — | 130.488 |
| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 29.021 | US$ 63 | — | 101.467 |
| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 3.000 | US$ 64 | — | 98.467 |
| 15 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 270 | US$ 65 | — | 98.197 |
| 16 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Uitoefening | 350 | US$ 18 | — | 98.547 |
| 16 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Uitoefening | 55.000 | US$ 15 | — | 153.547 |
| 16 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Uitoefening | 57.500 | US$ 27 | — | 211.047 |
| 16 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 65.104 | US$ 63 | — | 145.943 |
| 16 sep 2026 | ROTE WILLIAM E. | Chief Research Officer | Verkoop | 47.746 | US$ 64 | — | 98.197 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 39.283 | US$ 27 | — | 181.349 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 1.381 | US$ 22 | — | 182.730 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 36.526 | US$ 9 | — | 219.256 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 71.938 | US$ 62 | — | 147.318 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 27.421 | US$ 63 | — | 119.897 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 1.400 | US$ 64 | — | 118.497 |
| 15 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 1.431 | US$ 65 | — | 117.066 |
| 16 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 100.000 | US$ 11 | — | 217.066 |
| 16 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 55.000 | US$ 15 | — | 272.066 |
| 16 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 17.717 | US$ 27 | — | 289.783 |
| 16 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 93.604 | US$ 63 | — | 196.179 |
| 16 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 79.113 | US$ 64 | — | 117.066 |
| 17 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Uitoefening | 8.282 | US$ 22 | — | 125.348 |
| 17 sep 2026 | Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | Verkoop | 8.282 | US$ 65 | — | 117.066 |
| 15 sep 2026 | Inrig Jula | EVP, Head of R&D & CMO | Uitoefening | 32.395 | US$ 9 | — | 145.165 |
| 15 sep 2026 | Inrig Jula | EVP, Head of R&D & CMO | Verkoop | 25.390 | US$ 62 | — | 119.775 |
| 15 sep 2026 | Inrig Jula | EVP, Head of R&D & CMO | Verkoop | 17.284 | US$ 63 | — | 102.491 |
| 15 sep 2026 | Inrig Jula | EVP, Head of R&D & CMO | Verkoop | 1.600 | US$ 64 | — | 100.891 |
| 15 sep 2026 | Inrig Jula | EVP, Head of R&D & CMO | Verkoop | 400 | US$ 65 | — | 100.491 |
| 15 sep 2026 | REED ELIZABETH E | Chief Legal Officer and GC | Uitoefening | 37.500 | US$ 15 | — | 142.889 |
| 15 sep 2026 | REED ELIZABETH E | Chief Legal Officer and GC | Verkoop | 21.926 | US$ 62 | — | 120.963 |
| 15 sep 2026 | REED ELIZABETH E | Chief Legal Officer and GC | Verkoop | 13.874 | US$ 63 | — | 107.089 |
| 15 sep 2026 | REED ELIZABETH E | Chief Legal Officer and GC | Verkoop | 1.400 | US$ 64 | — | 105.689 |
| 15 sep 2026 | REED ELIZABETH E | Chief Legal Officer and GC | Verkoop | 300 | US$ 65 | — | 105.389 |
| 15 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Uitoefening | 95.666 | US$ 23 | — | 528.552 |
| 15 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 63.498 | US$ 62 | — | 465.054 |
| 15 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 28.796 | US$ 63 | — | 436.258 |
| 15 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 3.102 | US$ 64 | — | 433.156 |
| 15 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 270 | US$ 65 | — | 432.886 |
| 16 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Uitoefening | 195.841 | US$ 23 | — | 628.727 |
| 16 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 99.716 | US$ 63 | — | 529.011 |
| 16 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 96.125 | US$ 64 | — | 432.886 |
| 17 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Uitoefening | 108.493 | US$ 23 | — | 541.379 |
| 17 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 101.691 | US$ 65 | — | 439.688 |
| 17 sep 2026 | Dube Eric M | CHIEF EXECUTIVE OFFICER | Verkoop | 6.802 | US$ 65 | — | 432.886 |
| 15 sep 2026 | Cline Christopher R. | CHIEF FINANCIAL OFFICER | Uitoefening | 20.000 | US$ 17 | — | 138.016 |
| 15 sep 2026 | Cline Christopher R. | CHIEF FINANCIAL OFFICER | Verkoop | 27.473 | US$ 62 | — | 110.543 |
| 15 sep 2026 | Cline Christopher R. | CHIEF FINANCIAL OFFICER | Verkoop | 20.735 | US$ 63 | — | 89.808 |
| 15 sep 2026 | Cline Christopher R. | CHIEF FINANCIAL OFFICER | Verkoop | 1.900 | US$ 64 | — | 87.908 |
| 15 sep 2026 | Cline Christopher R. | CHIEF FINANCIAL OFFICER | Verkoop | 400 | US$ 65 | — | 87.508 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Uitoefening | 2.500 | US$ 28 | — | 44.853 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Uitoefening | 1.250 | US$ 22 | — | 46.103 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Uitoefening | 1.625 | US$ 20 | — | 47.728 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Verkoop | 4.275 | US$ 62 | — | 43.453 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Verkoop | 800 | US$ 63 | — | 42.653 |
| 15 sep 2026 | Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICER | Verkoop | 300 | US$ 64 | — | 42.353 |